Clindamicina [Inn-Spanish]
Brand names,
Clindamicina [Inn-Spanish]
Analogs
Clindamicina [Inn-Spanish]
Brand Names Mixture
Clindamicina [Inn-Spanish]
Chemical_Formula
C18H33ClN2O5S
Clindamicina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic2/clindam.htm
Clindamicina [Inn-Spanish]
fda sheet
Clindamicina [Inn-Spanish]
msds (material safety sheet)
Clindamicina [Inn-Spanish]
Synthesis Reference
Birkenmeyer, U.S. Pat. 3,475,407(1970)
Clindamicina [Inn-Spanish]
Molecular Weight
424.984 g/mol
Clindamicina [Inn-Spanish]
Melting Point
255 oC
Clindamicina [Inn-Spanish]
H2O Solubility
30.6 mg/L
Clindamicina [Inn-Spanish]
State
Solid
Clindamicina [Inn-Spanish]
LogP
1.224
Clindamicina [Inn-Spanish]
Dosage Forms
Capsules; Intramuscular solution; Intravenousparenteral solution; Topical solution; Topical lotion; Topical gel; Vaginal cream; Vaginal ovules
Clindamicina [Inn-Spanish]
Indication
For the treatment of serious infections caused by susceptible anaerobic bacteria (anaerobes, streptococci, pneumococci, and staphylococci)
Clindamicina [Inn-Spanish]
Pharmacology
Clindamycin is an antibiotic, similar to and a derivative of lincomycin. Clindamycin can be used in topical or systemic treatment. It is effective as an anti-anaerobic antibiotic and antiprotozoal.
Clindamicina [Inn-Spanish]
Absorption
- 90% - oral
Clindamicina [Inn-Spanish]
side effects and Toxicity
Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.
Clindamicina [Inn-Spanish]
Patient Information
Clindamicina [Inn-Spanish]
Organisms Affected
Enteric bacteria and other eubacteria